A bio-nanocapsule containing envelope (E) protein domain III of Japanese encephalitis virus (JEV) protects mice against lethal JEV infection
نویسندگان
چکیده
منابع مشابه
Transplacental Japanese encephalitis virus (JEV) infection in mice during consecutive pregnancies.
Transplacental transmission of Japanese encephalitis virus (JEV) has been demonstrated in consecutive pregnancies of mice. Pregnant mice inoculated intraperitoneally with JEV transmit the virus to the foetus. When such female mice were mated again after 6 months, the virus could be isolated from the foetuses of the ensuing pregnancy. The incidence of abortion was increased significantly though ...
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Directly acting antivirals recently have become available for the treatment of hepatitis C virus (HCV) infection, but there is no prophylactic vaccine for HCV. In the present study, we took advantage of the properties of Japanese encephalitis virus (JEV) to develop antigens for use in a HCV vaccine. Notably, the surface-exposed JEV envelope protein is tolerant of inserted foreign epitopes, perm...
متن کاملDescription of the disease: Japanese encephalitis virus (JEV) is a member of the genus Flavivirus in the family Flaviviridae and causes encephalitis, principally in horses and humans. JEV
Flavivirus in the family Flaviviridae and causes encephalitis, principally in horses and humans. JEV also infects pigs where it causes abortions and stillbirths. JEV is maintained in nature between mosquitoes, pigs and water birds. The major vector of JEV throughout most of Asia is Culex tritaeniorhynchus, however other species may be locally important. Pigs act as important amplifiers of the v...
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BACKGROUND Japanese encephalitis virus (JEV) is the most important cause of epidemic encephalitis in most Asian regions. There is no specific treatment available for Japanese encephalitis, and vaccination is the only effective way to prevent JEV infection in humans and domestic animals. The purpose of this study is to establish a new mammalian cell line stably and efficiently expressing virus-l...
متن کاملHumanized monoclonal antibody against West Nile virus envelope protein administered after neuronal infection protects against lethal encephalitis in hamsters.
Humans infected with West Nile virus (WNV) may clinically present with symptoms that are suggestive of neurological infection. Nearly all treatments of WNV disease have been effective in animal models only if administered before or soon after viral challenge. Here, we evaluated whether a potent neutralizing anti-WNV humanized monoclonal antibody (MAb), hE16, could improve the course of disease ...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2013
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.12055